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ea0090oc1.2 | Oral Communications 1: Diabetes, Obesity, Metabolism and Nutrition 1 | ECE2023

Semaglutide alters tongue transcriptome along with the improvement of taste perception and increased brain activation in response to sweet tasting solution in obese women with PCOS

Jensterle Mojca , Vovk Andrej , Kovac Jernej , Battelino Saba , Ferjan Simona , Hrast Barbara , Battelino Tadej , Janez Andrej

Background: Obese individuals may perceive the taste of caloric dense food as less intense, resulting in decreased activation of the reward system. Preclinical research provides some insights into the role of GLP-1 in the gustatory coding. The impact of GLP-1 receptor agonists on the tongue and taste perception remains largely unaddressed in clinical settings.Aim: to investigate the impact of semaglutide on the tongue transcriptome, taste perception and ...

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ea0073aep163 | Diabetes, Obesity, Metabolism and Nutrition | ECE2021

Semaglutide reduces fat accumulation in the tongue of obese women with polycystic ovary syndrome: A randomized, placebo-controlled prospective study

Jensterle Mojca , Ferjan Simona , Vovk Andrej , Battelino Tadej , Rizzo Manfredi , Janez Andrej

ObjectiveFat depot in the tongue that represents 2530% of the total tongue mass is largely unaddressed. It correlates with body mass index. The response to weight reduction induced by different anti-obesity modalities may vary between body fat compartments. Semaglutide, a long acting GLP-1 receptor agonist (GLP-1 RA), has the potential to reduce body mass with at least 2 to 3 times greater weight reduction than other studied GLP-1 RAs. This is the ...

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Endocrine Abstracts

Semaglutide alters tongue transcriptome along with the improvement of taste perception and increased brain activation in response to sweet tasting solution in obese women with PCOS

Semaglutide reduces fat accumulation in the tongue of obese women with polycystic ovary syndrome: A randomized, placebo-controlled prospective study

BiosciAbstracts